Yoon A Kim, Tohid Siddiqui, Jennifer Blaze, Mehmet Ilyas Cosacak, Tristan Winters, Atul Kumar, Ellen Tein, Andrew A Sproul, Andrew F Teich, Francesca Bartolini, Schahram Akbarian, Caghan Kizil, Gunnar Hargus, Ismael Santa-Maria. (2023) RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathol. Jan;145(1):29-48. doi: 10.1007/s00401-022-02511-7. Epub 2022 Nov 10.

Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus, Philippe Tixador, Andrew A Sproul, Bernard Brugg, Michelle Reboud-Ravaux, Carol M Troy, Michael L Shelanski, Serge Bouaziz, Michael Karin, Chahrazade El Amri, Etienne D Jacotot. (2022) Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. Nov 15;13(11):959. doi: 10.1038/s41419-022-05396-2.

Martínez-Hernández J, Parato J, Sharma A, Soleilhac JM, Qu X, Tein E, Sproul A, Andrieux A, Goldberg Y, Moutin MJ, Bartolini F, Peris L. Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease. Front Cell Dev Biol. 2022 Aug 26;10:926914. doi: 10.3389/fcell.2022.926914.eCollection 2022.

Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis Jr., So Yeon Koo, Archana Ashok, Georges MairetCoello, Sebastien Herzig, Reuben Shaw, Andrew Sproul, Franck Polleux. Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nature Communications 2022 Aug 1;13(1):4444. doi: 10.1038/s41467-022-32130-5.

Leticia Peris, Julie Parato, Xiaoyi Qu, Jean-Marc Soleilhac, Fabien Lanté, Atul Kumar, Maria Elena Pero, José Martínez-Hernández, Charlotte Corrao, Giulia Falivelli, Floriane Payet, Sylvie Gory-Fauré, Christophe Bosc, Marian Blanca Ramirez, Andrew Sproul, Jacques Brocard, Benjamin Di Cara, Philippe Delagrange,6 Alain Buisson,1 Yves Goldberg,1 Marie-Jo Moutin,1,† Francesca Bartolini2,† and Annie Andrieux. (2022) Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer’s disease. Brain Feb 11;awab436. doi: 10.1093/brain/awab436. PMID: 35148384.

Andrew A. Sproul. Chapter 6: Targeting Alzheimer’s disease and related dementias with CRISPR and human pluripotent stem cell technologies. (2021) CRISPR Genome Surgery in Stem cells and Disease Tissues. Edited by Stephen Tsang, Elsevier.

Song S, Ashok A, Williams D, Kaufman M, Duff K, Sproul A. (2021) Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors. Current Protocols Jun;1(6):e141. doi: 10.1002/cpz1.141.PMID: 34102035. PMID: 34102035.

Lu, TM, Houghton S,  Magdeldin T,  Durán JGB,  Minotti AP, Snead A, Sproul A, Nguyen DHT, Xiang J,  Fine HA, Rosenwaks Z, Studer L, Rafii S, Agalliu D, Redmond D, Lis R. (2021) Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate. Proc Natl Acad Sci U S A  Feb 23;118(8):e2016950118.doi: 10.1073/pnas.2016950118. PMCID: PMC7923590.

M. Pera, D. Larrea, J. Montesinos, C. Guardia,Laguarta, R.R. Agrawal, K.R. Velasco, Y. Xu, SY Koo, A Snead, A. Sproul, E. Area-Gomez (2020). The C99 Fragment Of App Regulates Cholesterol Trafficking. EMBO J. Oct 15;39(20):e103791. doi: 10.15252/embj.2019103791. 

Martín-Maestro P, Sproul A, Martinez H, Paquet D, Gerges M, Noggle S, Starkov AA. (2019) Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells. Molecular Neurobiology Jun 16. doi: 10.1007/s12035-019-01665-y. PMID: 31203573.

Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. (2019) CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nature Communications. 10(1):53. doi: 10.1038/s41467-018-07971-8. PMID: 30604771.

Chung, KM, Hernandez, NC, Sproul, AA and WH Yu (2018). Digesting Macroautophagic Changes in Alzheimer’s disease. Neuroscience Letters S0304-3940(18)30344-6. doi: 10.1016/j.neulet.2018.05.017. PMID: 29758300.

Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. (2017) CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons. Acta Neuropathol Commun. 5(1):77. doi: 10.1186/s40478-017-0475. PMID: 29078805.

Martín-Maestro P, Gargini R, A Sproul A, García E, Antón LC, Noggle S, Arancio O, Avila J, García- Escudero V. (2017) Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. Front Mol Neurosci. 10:291. doi: 10.3389/fnmol.2017.00291. PMID: 28959184.

Paquet D, Kwart D, Chen A, Sproul A, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S, Tessier-Lavigne M. (2016) Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9. Nature. 5;533(7601):125-9. PMID: 27120160.

Sproul, AA. (2015) Being human: The role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer's disease models. Mol Aspects Med. 43-44:54- 65. doi: 10.1016/j.mam.2015.06.007. PMID: 26101165.

Nestor MW, Jacob S, Sun B, Prè D, Sproul AA, Hong SI, Woodard C, Zimmer M, Chinchalongporn V, Arancio O, Noggle SA. (2015) Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies. Am J Physiol Cell Physiol. Feb 1;308(3):C209-19. doi: 10.1152/ajpcell.00263.2014. Epub 2014 Nov 12. PMID: 25394470.

Pre D., Nestor MW*, Sproul AA*, Koppensteniner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle SA, Arancio O. (2014) A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). PLoS ONE 9, e103418. doi: 10.1371/ journal.pone.0103418. eCollection 2014. PMID: 25072157.

Sproul, AA, Jacob S, Pre D, Kim, SH, Nestor MW, Navarro-Sobrino, M, Santa Maria, I, Zimmer, M, Aubrey S, Steele MW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA.  (2014) Characterization and Molecular Profiling of PSEN1  Familial Alzheimer's Disease iPSC-Derived Neural Progenitors. PLoS ONE 9, e84547. doi: 10.1371/journal.pone.0084547. PMID: 24416243.

Sproul AA, Vensand LB, Dusenberry CR, Jacob S, Vonsattel JP, Paull DJ, Shelanski ML, Crary  JF, Noggle SA. (2014) Generation of iPSC lines from archived non-cryoprotected biobanked dura mater. Acta Neuropathol Commun. 2, 4. doi: 10.1186/2051-5960-2-4. PMID: 24398250.

Nestor MW, Paull D, Jacob S, Sproul AA, Alsaffar A, Campos BA, Noggle SA. (2013)  Differentiation of serum-free embryoid bodies from human induced pluripotent stem cells into networks. Stem Cell Res.10(3):454-63. doi: 10.1016/j.scr.2013.02.001. Epub 2013 Feb 13. PMID: 23500645.

Kahler DJ, Ahmad FS, Ritz A, Hua H, Moroziewicz DN, Sproul AA, Dusenberry   CR, Shang L, Paull D, Zimmer M, Weiss KA, Egli D, Noggle SA (2013) Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting. PLoS One. 8(3):e59867. doi:10.1371/journal.pone.0059867. DOI:10.1371/journal.pone.0059867. PMID: 23555815.

Wilhelm, M., Kukekov, N., Schmitt, TL., Bisgas, K., Sproul, A., Gire,S., Maes, ME., Xu, Z., and Greene,LA. (2011) Sh3rf2/POSHER protein promotes cell survival by Ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (plenty of SH3s) protein. J Biol Chem. 287 (3) 2247-56. DOI:10.1074/jbc.M111.269431. PMID: 22128169.

Sproul, A., Xu, Z., Wilhelm, M., Gire, S., and Greene, L. (2009) Cbl negatively regulates JNK activation and cell death. Cell Research. 19: 950-961. DOI: 10.1038/cr.2009.74. PMID: 19546888.

Biswas, S., Shi, Y., Sproul, A., Greene L. (2007) Pro-apopototic Bim induction in response to NGF deprivation requires simultaneous activation of three different death signaling pathways. J Biol Chem. 282 (40) 29368-74. DOI: 10.1074/jbc.M702634200. PMID: 17702754.

  Xu, Z., Sproul, A., Wang, W. Kukevov, N. and Greene, L. (2006) Siah1 interacts with the scaffold proteinPOSH to promote JNK activation and apoptosis. J Biol Chem. 281(1): 303-312. DOI: 10.1074/jbc.M509060200. PMID: 16230351. 

Sproul, A., Lambourne, T., Jean-Jacques D., J., and Kornberg, H. (2001) Genetic control of manno(fructo)kinase activity in Escherichia coli. Proc Natl Acad Sci USA. 98(26):15257-9. DOI: 10.1073/pnas.211569798. PMID: 11742072.

 Kornberg, H., Lambourne T., and Sproul, A. (2000) Facilitated diffusion of fructose via the phosphoenolpyruvate/glucose phosphotransferase system of Escherichia coli. Proc Natl Acad Sci USA. 97 (4), 1808-12. PMID: 10677538.